H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation
Enhancers Lego Minifigure play a central role in cell-type-specific gene expression and are marked by H3K4me1/2.Active enhancers are further marked by H3K27ac.However, the methyltransferases responsible for H3K4me1/2 on enhancers remain elusive.Furthermore, how these enzymes function on enhancers to regulate cell-type-specific gene expression is un